momelotinib (Rx)

Myelofibrosis
Indicated for intermediate or high-risk myelofibrosis (MF), including primary MF or secondary MF [post polycythemia vera (PV) and post essential thrombocythemia (ET)], in adults with anemia
200 mg PO daily
Dosage Modifications
Discontinue in patients unable to tolerate 100 mg daily
Thrombocytopenia
May reinitiate or increase dose up to starting dose as clinically appropriate
Reduce daily dose by 50 mg from last given dose if
Baseline ≥100 x 109/L, then decreased to 20 to <50 x 109/L
Interrupt treatment until platelets recover to 50 x 109/L if
Baseline ≥100 x 109/L, then decreased to <20 x 109/L
Baseline 50 to <100 x 109/L, then decreased to <20 x 109/L
Restart at a daily dose of 50 mg below the last given dose
May reinitiate treatment at 100 mg if previously dosed at 100 mg
……see more…

https://reference.medscape.com/drug/ojjaara-momelotinib-4000329

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