mitoxantrone (Rx)

Dosage Forms & Strengths

injectable solution

• 2mg/mL

Secondary Progressive Multiple Sclerosis

12 mg/m² short IV (5-15 minutes) infusion q3Months  

Not to exceed lifetime cumulative dose of 140 mg/m²

Acute Nonlymphocytic Leukemia

Induction

• 12 mg/m²/day IV on days 1-3 with cytarabine 100 mg/m²/day IV contunuous infusion on days 1-7  

• Second induction with same doses of mitoxantrone for 2 days & cytarabine for 5 days may be given if incomplete antileukemic response & no severe nonhematologic toxicity in first induction

• Consolidation: 12mg/m²/day for 2 days, repeat in 4 weeks

https://reference.medscape.com/drug/mitoxantrone-342186

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