loncastuximab tesirine (Rx)

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Dosage Forms & Strengths

injection, lyophilized powder for reconstitution

10mg/vial

Large B-Cell Lymphoma

Indicated for relapsed or refractory large B-cell lymphoma after ≥2 lines of systemic therapy, including diffuse large B-cell lymphoma (DLBCL) not otherwise specified, DLBCL arising from low-grade lymphoma, and high-grade B-cell lymphoma

Cycles 1-2: 0.15 mg/kg IV q3Weeks

Cycle 3 and thereafter: 0.075 mg/kg IV q3Weeks

Dosage Modifications

If dosing delayed >3 week owing to toxicity, reduce subsequent doses by 50%; if toxicity reoccurs despite dose reduction, consider discontinuation

If toxicity requires dose reduction following second dose of 0.15 mg/kg (Cycle 2), reduce dose to 0.075 mg/kg for Cycle 3

https://reference.medscape.com/drug/zynlonta-loncastuximab-tesirine-4000190

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