ensartinib (Rx)
Dosage Forms & Strengths
capsule
Non-Small Cell Lung Cancer (NSCLC)
Indicated for treatment of adults with anaplastic lymphoma kinase (ALK)-positive locally advanced or metastatic NSCLC as detected by an FDA-approved test who have not previously received an ALK-inhibitor
225 mg PO daily until disease progression or unacceptable toxicity
Dosage Modifications
Recommended dosage reductions
First reduction: 200 mg PO daily
Second reduction: 150 mg PO daily
Permanently discontinue if unable to tolerate 150 mg PO daily
Do not subsequently increase dose after dosage reduction
Interstitial lung disease (ILD)/pneumonitis
Dermatologic adverse reactions
https://reference.medscape.com/drug/ensacove-ensartinib-4000460
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