chlorambucil (Rx)

Dosage Forms & Strengths

tablet

• 2mg

Chronic Lymphatic (Lymphocytic) Leukemia

0.1 mg/kg/day for 3-6 weeks or  

0.4 mg/kg (increased by 0.1 mg/kg/dose until response/toxicity observed) biweekly or

0.4 mg/kg (increased by 0.1 mg/kg/dose until response observed) monthly or

0.03-0.1 mg/kg/day continuously

Reduce initial dose if administered within 4 weeks after a full course of radiation/myelosuppressive therapy or patients with bone marrow disease

Not to exceed 0.1 mg/kg/day if bone marrow infiltrated with lymphocytes

Hodgkin’s Lymphoma

0.2 mg/kg/day for 3-6 weeks or  

0.4 mg/kg (increased by 0.1 mg/kg/dose until response/toxicity observed) biweekly or

0.4 mg/kg (increased by 0.1 mg/kg/dose until response or toxicity observed) monthly or

0.03-0.1 mg/kg/day continuously

Reduce initial dose if administered within 4 weeks after a full course of radiation/myelosuppressive therapy or patients with bone marrow disease

Not to exceed 0.1 mg/kg/day if bone marrow infiltrated with lymphocytes

https://reference.medscape.com/drug/leukeran-chlorambucil-342112

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