procarbazine (Rx)

Hodgkin’s Disease

Part of COPP, BEACOPP and MOPP regimens

2-4 mg/kg/day in single or divided doses for 7 days; increase dose by 4-6 mg/kg/day until maximum response obtained or WBC<4,000 cells/mm³ or platelets<100,000 cells/mm³; reduce dosage to 1-2 mg/kg/day after maximum effect obtained  

Alternatively, 100 mg/m² PO qDay for 7-14 days of each 28 day cycle in combo with other antineoplastics  

Monitor: CBC

Glioma (Orphan)

Treatment of malignant glioma

Orphan indication sponsor

• Sigma-Tau Pharmaceuticals, Inc; 9841 Washingtonian Blvd, Suite 500; Gaithersburg, MD 20878

……see more….

https://reference.medscape.com/drug/matulane-procarbazine-342101

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