busulfan

Dosing & Uses
Dosage Forms & Strengths
injectable solution
6mg/mL
tablet
2mg
Chronic Myelogenous (Myeloid, Myelocytic, Granulocytic) Leukemia
Pre-medicate with anticonvulsants (e.g. benzodiazepines, phenytoin, valproic acid or levetiracetam) and antiemetic
Remission induction: 60 mcg/kg/day or 1.8 mg/m²; 4-8 mg PO qDay usual range
Maintenance doses: 1-4 mg/day to 2 mg/week PO to maintain WBC 10,000-20,000 cells/mm³ may withhold drug when leukocyte count has declined to approximately 15,000/mcL
Examine patient at monthly intervals and resume treatment with induction dosage when total leukocyte count reaches approximately 50,000/mcL
Administered as component of busulfan/cyclophosphamide: 0.8 mg/kg IV q6hr for 4 days (in combo with cyclophosphamide) until WBC count= 15,000/mm³
Administration: take on empty stomach to decrease risk of N/V
Monitor: CBC, Hgb, LFTs
……see more….

https://reference.medscape.com/drug/myleran-busulfex-busulfan-342104

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